He was the son of Francesco, duke of Martina and count of Buccino, making him nephew of Innico Caracciolo the Elder.

On 10 February 1690 he was made secretary of the Holy Congregation for the discipline of Regular Clergy and of Apostolic Visit.

[2] He was elected bishop of Aversa on 25 February 1697 and ordained on 24 March the same year at Chiesa Nuova by cardinal Galeazzo Marescotti, assisted by Francesco Pannocchieschi, archbishop of Pisa and Carlo Loffredo, Archbishop of Bari-Bitonto.

[3][4] He was made clerk of the Camera Apostolica under pope Clement XI and Apostolic Nuncio to Switzerland in 1712.

He gave away his stipend and his inheritance to help the poor of the diocese, called a diocesan synod, restored Aversa Cathedral and founded a classical lyceum.