Insanitarium

Insanitarium is a 2008 American direct-to-video horror-thriller film starring Jesse Metcalfe, Kiele Sanchez, Kevin Sussman, Olivia Munn, Carla Gallo and Peter Stormare.

Jack (Jesse Metcalfe) goes undercover as a new patient in order to save his sister, Lily (Kiele Sanchez), who has been involuntarily institutionalized for reasons unknown.

The two siblings band together with a terminally paranoid man, Dave (Kevin Sussman), and a helpful nurse, Nancy (Olivia Munn), in the hopes of finding a way out of the asylum.

They are attacked by most of the prisoners and staff, who kill Nancy; while on the 4th floor, they encounter Gianetti, who gives Dave an icepick lobotomy, incapacitating him; he attempts to get Jack too, but ends up being infected by Loomis.

Stormare improvised many parts of his role, including the "panties in the mouth" scene with Carla Gallo, who plays Vera, his research assistant.