Intercultural Institute of Ayuuk (ISIA) (Instituto Superior Intercultural Ayuuk) is a small Jesuit University in the indigenous region of the Mixe people in Jaltepec de Candayoc, Oaxaca, Southern Mexico.

It addresses the desire of the Mixe people to preserve their livelihood and culture amidst contrary global forces.

[6] Ayuuk's work in inculturated communication has been successful in "reducing the digital divide.

"[7] And its work toward sustainable development has received the support of Tierra international which installed solar panels for the school while teaching the technology to students and faculty.

[8] The institute follows the local custom of “collective work”: every student has a job related to the upkeep and development of the school.