[7] The IL20RA receptor is involved in both pro-inflammatory and anti-inflammatory responses, signaling through the JAK-STAT pathway.

[5] IL20RA is found in the skin, lungs, ovaries, testes and placenta, with low gene expression in the intestine and liver.

IL20RA also forms a complex with the IL-10 receptor, beta subunit, which binds the cytokine IL-26.

[5] In this pathway, after a cytokine binds IL20RA and the beta subunit, JAKs linked to intracellular domains of IL20R activate and phosphorylate tyrosine residues found in the longer alpha chains of IL20RA.

STATs then dimerize and move to the nucleus to act as transcription factors.