4P0J, 4P0K, 4P0L2652554450ENSG00000136695ENSMUSG00000026983Q9UBH0Q9QYY1NM_173170NM_012275NM_001146087NM_001146088NM_019451NP_036407NP_775262NP_001139559NP_001139560NP_062324Interleukin 36 receptor antagonist (IL-36RA) is a member of the interleukin-36 family of cytokines.

It was previously named Interleukin-1 family member 5 (IL1F5).

[5][6][7][8] The protein is known to inhibit the effects of Interleukin-36 cytokines (IL-36α, IL-36β and IL-36γ) via competing with their receptor IL-36R/IL1RL2 and thereby inhibiting their proinflammatory effects.

[9] Mutations in the IL-36RN gene resulting in a decrease or production of defective IL-36RA protein have been shown to cause inflammatory skin diseases including generalised pustular psoriasis, acrodermatitis continua suppurativa Hallopeau (ACH) and acute generalized exanthematous pustulosis (AGEP).

[10]