[5][6] IL20RB is found in many organ resident effector cells such as keratinocytes at the skin epidermis, osteoclasts, found in bones, and epithelial cells of the intestine and trachea.

This signaling pathway leads STAT to act as a transcription factor, which can gene expression.

[6] IL20RB is linked with atherosclerosis and gastrointestinal diseases, although its specific roles are unknown.

[6] IL20RB mRNA is expressed in retinal ganglion cells and optic nerves in rats.

The specific links between IL20RB and glaucoma are unknown, but IL20RB does not have a causative effect on the disease, instead contributing to an increased risk of the disease along with other factors, such as intraocular pressure.