Interstate 180 (I-180) is a spur highway in Pennsylvania that connects Williamsport to I-80 near Milton.

I-180 begins along the banks of the West Branch Susquehanna River in Williamsport, at an interchange with I-99, U.S. Route 15 (US 15), and US 220.

At exit 27A, US 15 leaves the overlap running south across the Carl E. Stotz Memorial Little League Bridge, and I-180 continues eastward, still concurrent with US 220 northbound.

From there, I-180 runs along the West Branch Susquehanna River until the highway reaches the eastern suburbs of Williamsport, where US 220 leaves the Interstate via exit 15.

I-180 terminates at an interchange with I-80, and the freeway continues as Pennsylvania Route 147 (PA 147).