By avoiding Downtown Jackson, it also offers a different route for those traveling from I-55 south to I-20 west and from I-20 east to I-55 north.

Secondary signs at the terminuses direct drivers to use the route as a shortcut to Memphis, Tennessee, and Vicksburg.

Its exits start with a partial cloverleaf interchange for US Highway 80 (US 80) west toward Clinton and east toward Pearl.

This $13.4-million (equivalent to $20.7 million in 2023[3]) project completed a diamond interchange constructed at Industrial Drive between the Clinton Boulevard and US 49 north junctions.

The project also resulted in the expansion of I-220 from four to six lanes from Clinton Boulevard (exits 2A and 2B) northward to Industrial Drive.