The western terminus connects with I-10 east of Sulphur, heading southeast as it bypasses central Lake Charles around the southside.

I-210 heads east through Lake Charles, turning 90 degrees at exit 8, LA 14/Gerstner Memorial Drive.

[3] I-210, including the Israel LaFleur Bridge, was constructed between its western terminus and Prien Lake Road circa 1963 to 1965.

The eastern remainder of I-210 was built circa 1975 to 1976,[5] and westbound entrance / eastbound exit ramps were added to the western terminus in 1986.

The freeway remained largely unchanged from its original configuration until 2005, when construction of the L'Auberge du Lac Casino Resort resulted in the addition of a ramp linked to the Nelson Road interchange.