The I-555 route was approved on January 10, 2001, consisting of a widened section of US 63 between Turrell to Jonesboro to Interstate Highway standards.

A few mainline bridges between Marked Tree and Turrell are from original two-lane US 63 and are narrower than current standards, but I-530 was approved in 1999 despite having a similar issue.

The exemption was introduced by U.S. Representative Rick Crawford and passed as part of the House Transportation Bill on December 4, 2015.

[4] In early 2016, signs along the section of the highway cautioned travelers that there may be farm equipment driving on the roadway.

[6] ARDOT is currently running studies that will determine whether improvements to interchanges and cross-streets are needed for I-555 in Craighead County.