After two miles (3.2 km), I-84 splits from I-380, as the latter goes southeasterly through the Poconos and I-84 continues almost due east into Wayne and Pike counties.

[citation needed] This section of Pennsylvania is very lightly populated, and there are no major settlements on or near I-84, although it offers access to popular outdoor recreation areas such as Lake Wallenpaupack and Promised Land State Park.

Its right-of-way is very wide, with a large median strip between the two carriageways as it passes through densely wooded country, except for the swampy areas in southern Wayne County.

The only development along Pennsylvania's section of I-84 is where U.S. Route 6 (US 6) and US 209 start to parallel closely and form a commercial strip just south of Matamoras, just west of the Delaware River.

[4] I-84 was to continue west of I-380 and connect to I-81 at Moosic, but the alignment was moved further north, running concurrently with I-380 from Elmhurst Township to Dunmore.