Connecting service by the Baltimore and Ohio Railroad offered continuing service south from Philadelphia to Washington, D.C.[1] The train was presented as affording Washington to Syracuse travel.

However, by 1949 the Interstate Express did not stop at Wayne Junction in the northbound direction; so, passengers would need to transfer at Lansdale station.

Riders seeking to transfer in Philadelphia would need to disembark at the B&O's 24th & Chestnut Station in Philadelphia, take a cab or the Market Street subway to Reading Terminal for the originating northbound DLW train.

The Binghamton to Syracuse segment was joined by cars from a direct DLW Railroad train from that company's Hoboken Terminal.

The connecting Washington to Philadelphia service offered a dining car-parlor car.