Ioannis Roufos (Greek: Ιωάννης Ρούφος, 1870-1908) was a Greek politician.
He was the son of Georgios Rouphos, a politician and the 11th Mayor of Patras and a grandson of Benizelos Roufos, a Prime Minister of Greece and Mayor of Patras, he is descended from the Rouphos-Kanakaris families with many generations of politicians and descended from southern Italy.
He was a politician of Achaea in 1899, he died early in 1908.
The newspaper Neologos wrote on his death in which the Public Council in it did not receive voting condolescences.