[2]: 37 Donald G. Davis noted that Wilshire had severe headaches which doctors in the United States and Europe failed to cure.
[4]: 111 On 18 November 1926 Wilshire challenged the California medical profession to investigate his device in a full-page advertisement in the Los Angeles Times.
[4]: 109–111 Arthur J. Cramp of the American Medical Association (AMA) responded to Wilshire's letter with an article that critically analyzed the claims regarding the Ionaco.
[5] Wilshire's concept for his electric belt and his theory of electromagnetic health was influenced by Otto Heinrich Warburg's study of iron in the blood.
[2]: 37–38 The belt was marketed as both a health-improving device and a cure for most diseases; including cancer, diabetes, tuberculosis, arthritis, neuritis, and insomnia.
[4]: 109 Wilshire and his company marketed the electric device to those most likely to use it, including phone subscribers and power plant customers.
In-house sales associates called demonstrators provided both paid and free treatments for potential buyers.
[2]: 35 In 1928 Philip Ilsey, the former manager of the Iona Company in Cleveland, started marketing an Ionaco clone called the Theronoid.
Shortly after the development of the device Wilshire himself died of a disease of the kidney in a New York hospital, no doubt without the benefit of his own invention.