Irene Guerrero Sanmartín (born 12 December 1996) is a Spanish professional footballer who plays as a central midfielder for Liga MX Femenil side Club América and the Spain national team.

In 2020, Guerrero was recruited by her former Betis coach María Pry who had joined Levante UD the previous season.

On 18 August 2021, she made her UEFA Women's Champions League debut during the first qualifying round, starting in a 2–1 victory over Celtic.

Guerrero was selected to represent Spain at UEFA Women's Euro 2022, making two appearances, once as a substitute and once as a starter.

However, in the wake of the Rubiales affair, Guerrero was one of the 81 players who signed a letter denouncing abuse in the RFEF and saying they would boycott the national team until its leadership changed.