The Iriondo Department (in Spanish, Departamento Iriondo) is an administrative subdivision (departamento) of the province of Santa Fe, Argentina.

It limits with the departments of San Jerónimo in the north, San Lorenzo in the east, Caseros in the south, and Belgrano in the west.

It is one of only three departments in Santa Fe that do not border another province.

Other cities and towns are Bustinza, Carrizales, Classon, Correa, Lucio V. López, Oliveros, Pueblo Andino, Salto Grande, Serodino, Totoras, and Villa Eloísa.

This article about a place in Santa Fe Province, Argentina is a stub.