Probably he was the son of a former slave,[1] Isaac David Burrell first attended Lincoln University (Pennsylvania) and later received an M.D.
His wife, Margaret Barnette Burrell (1873–1970) from Lynchburg, Virginia, was also recognized as a society leader in Roanoke.
He died on March 21, 1914, in Washington, D.C. His death was the impetus for several Black physicians of Roanoke to open a hospital for their patients.
The hospital also was established without support from the whites, and had the first African-American School of Nursing to be accredited in Virginia.The building, now called The Burrell Center, houses Blue Ridge Behavioral Healthcare offices and clinic.
[6] The location of his pharmacy was examined by archaeologists who found more than 30,000 artifacts, including some bottles still containing pills and Elixirs.