The Isaac H. Lionberger House at 3630 Grandel Square in Midtown St. Louis, Missouri, is the last private residence designed by noted American architect Henry Hobson Richardson.

[1] Designed in 1885–86, the building was built after Richardson's death.

It was built for Isaac H. Lionberger, a well-known St. Louis lawyer who later became Assistant Attorney General of the United States.

[2] The Lionberger House became a St. Louis Landmark in 1975.

[2] In 2005, the house was restored and divided into office and residential space.