Buildings in the district were designed by notable architects including Henry Hobson Richardson, Eames and Young, William B. Ittner, Preston J. Bradshaw, C. Howard Crane, Brad Cloepfil and Tadao Ando.

is the sumptuous, Neo-classical acoustically vibrant home of the St. Louis Symphony and another is a thriving live performance venue, (the Fox Theatre).

Buildings designed for worship are performing arts centers (Sheldon Concert Hall and the Grandel Theatre).

City Foundry is a $220 million, 15-acre project that was undertaken by the Lawrence Group and CEO Steve Smith, who sought to create a new recreational and business complex in the center of Midtown, St. Louis.

[2] The project is located in the heart of Midtown St. Louis, Missouri, with the goal of promoting economic development within the shrinking city.

[3] By using a biophilic design, creating a pedestrian-only walkway, and connecting the recreational and business complex to the Brickline Greenway, the hub attempts to foster greater social connection and act as a destination spot within the city, bringing the community and visitors together to foster a greater sense of belonging.

The only American Civil War battle in St.Louis, the Camp Jackson Affair, took place on May 10, 1861, when Union military forces clashed with civilians after capturing the Confederate Missouri Volunteer Militia commanded by General Daniel M. Frost.

However, in the 1970s, Father Paul C. Reinert, President of Saint Louis University inspired the urban renewal effort to rehabilitate the neighborhood and make use of its surviving buildings that continues in the Twenty-First Century.