Isaac Komnenos Vatatzes (Greek: Ἰσαάκιος Κομνηνός Βατάτζης; died 1196) was a Byzantine aristocrat and military commander, who was the son-in-law of Emperor Alexios III Angelos and received the rank of sebastokrator.
[7][8] In the summer of 1195, the Bulgarian rebels attacked the region around Serres, and captured the local Byzantine commander, Alexios Aspietes.
[9][10] According to the contemporary official and historian, Niketas Choniates, the rebels were initially hesitant to confront Isaac's army, and withdrew to raid the valley of the Strymon River.
[19][20] Due to her young age, the marriage, if there ever was one, was never consummated; Theodora remained in Constantinople, while Ivanko rose in revolt in 1199, only to be captured and imprisoned by a ruse.
[23][24] After Isaac's death, his wife remarried, in 1199/1200, to Theodore Laskaris, the future founder of the Empire of Nicaea (r. 1204–1222).