Isaacs Creek is a stream in Ripley County in the U.S. state of Missouri.
[2] The stream headwaters arise at 36°42′34″N 90°50′02″W / 36.7094444°N 90.8338889°W / 36.7094444; -90.8338889 at an elevation of approximately 585 feet.
It flows to the southwest entering the Mark Twain National Forest and then turns to the south and flows roughly parallel to Missouri Route Y.
It crosses under Route Y and enters the Current at 36°39′18″N 90°51′37″W / 36.655058°N 90.860401°W / 36.655058; -90.860401 approximately 2.5 miles northwest of Doniphan and an elevation of 341 feet.
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