Isabel Godin des Odonais (1728 in Riobamba, Viceroyalty of Peru, now in Ecuador – 28 September 1792 in Saint-Amand-Montrond, Cher, France) was an 18th-century woman who became separated from her husband in South America by colonial politics, and was not reunited with him until more than 20 years later.

Her long difficult journey in the 18th century, from western Peru to the mouth of the Amazon River, is considered extraordinary in the history of South America.

In 1749, her husband, Jean Godin des Odonais, left their home in Riobamba, Ecuador, Spanish South America to visit French Guiana.

She was well-educated and spoke fluent Spanish, French, and Quechua, and understood the use of quipus, the Incan method of communicating information using colored strings and knots.

Jean Godin des Odonais was a French cartographer and naturalist who had joined the world's first geodesy expedition to the equator.

Upon arriving in Cayenne, Godin found the Portuguese and Spanish colonial authorities would not let him — a Frenchman of no importance — return through their territory.

Eventually, La Condamine wrote on Godin's behalf to the Portuguese king, who due to changing political circumstances was eager to befriend the French.

However, as Godin had written some incendiary letters against the Portuguese, he was suspicious of the offer of passage up the Amazon, and abandoned the ship at its first port.

The route across the Andean mountains and Amazon Basin was arduous, made worse by the recent devastation by smallpox of the mission station at Canelos (in present-day Pastaza Province), depriving the party of valuable support nine days into their journey.

Unable to identify Isabel's body, he sent word of her death to Don Pedro — news which later reached Jean Godin.