He primarily battled the superhero team the All-Winners Squad, and was particularly obsessed with members the Whizzer and Miss America.

[2] Simon Meke, the secretary of museum curator Professor Saba, planned to take over the world by stealing an atom bomb.

While the superheroes were kept busy by battle, Isbisa created a sleeping gas that he used on the workers at the Atom Smasher Vacuum Tube.

In 1949, he escaped and learned that two members, Miss America and the Whizzer, were acting as bodyguards for a nuclear project.

Frank managed to release Nuklo from his containment and then charge Isbisa, who killed the aged hero.

When Scarlet Witch and the Vision recover and attack him, Isbisa attempts to release all his stored-up radiation in a bid to kill them.

the She-Hulk) court cases, Isbisa, disguised as a Professor Sanderson, transports the supervillain Venom from a past battle with Spider-Man and into the courthouse.

She-Hulk battled numerous time-displaced villains until her confidante, former Blonde Phantom Louise Mason, deduced who was behind these events.