Iserlohn station was opened in 1864,[4] together with the line from Letmathe, which was extended to Hemer in 1885, connecting to Fröndenberg.

[4] The Letmathe–Fröndenberg railway between Iserlohn Ost station and Hemer was closed in 1989 because of the deterioration of a bridge on the line, which was not considered worth repairing.

Since the dismantling of the line and the removal of the last set of points, Iserlohn station has been classified as a Haltepunkt (halt).

However, the Zweckverband SPNV Ruhr-Lippe (association for the promotion of public transport in Ruhr-Lippe, ZRL) intends to build a connection between the two lines, including points, which would restore its status as a bahnhof (station).

In addition to the typical tenants (ticket counter, food sales), the station building also has a tourist information office and a community college.