Isham Talbot (1773 – September 25, 1837) was a United States Senator from Kentucky.

He was admitted to the bar, and began his legal practice in Versailles, Kentucky.

He was then elected as a Democratic Republican to the United States Senate to fill the vacancy caused by the resignation of Senator Jesse Bledsoe, and served from February 2, 1815, to March 3, 1819.

The second time he was elected to the United States Senate was to fill the vacancy caused by the resignation of William Logan, and served from October 19, 1820, to March 3, 1825.

He then resumed his law practice and died on his plantation near Frankfort.