[4] Pacheco was heavily recruited by Syracuse, Maryland, Rutgers, Virginia Tech, and other football programs along the East Coast.

[7] Pacheco was selected in the seventh round with the 251st overall pick of the 2022 NFL draft by the Kansas City Chiefs.

[13] In a Week 11 matchup against the Los Angeles Chargers, Pacheco rushed for a career-high 107 yards on 15 carries.

[15] In his first professional season, Pacheco was the starting running back for the Chiefs in Super Bowl LVII.

In the Super Bowl, Pacheco had 76 yards and a touchdown as the Chiefs defeated the Philadelphia Eagles 38–35.

[16] Following the season, Pacheco underwent surgeries to repair a torn labrum and broken hand, which he stated he had played through during the Super Bowl.

[28] He played in Super Bowl LIX, recording 12 scrimmage yards in the 40–22 loss to the Eagles.