He was the brother of Ali Amirkhizi, a constitutional revolutionary, writer and political activist, member of the Central Committee of the Tudeh Party of Iran.

[2][3] Ismail Amirkhizi was born in 1873 in "Arvanagh region", Sufian District, East Azerbaijan Province, Iran.

[2][1] From the beginning of the constitutional movement, he joined the group of freedom fighters and participated in the Azerbaijan Provincial Association as the representative of the city of Ardabil.

In 1912, as a result of the Russian occupation of Tabriz and the pressure of the supporters of tyranny, he emigrated to Istanbul, and from there he went to Berlin at the invitation of Hassan Taqizadeh and worked in the Committee of Iranian Nationalists.

[2][6][8] After the suppression of the uprising and Khiabani's assassination, Amirkhizi suddenly withdrew from politics and turned to cultural affairs.

In 1942, he returned to Tabriz and became the director of one of Azerbaijan culture centers, but twenty months later he was transferred to Tehran at his own request.