Cyclic isodizenes in particular readily undergo cycloelimination and chelotropic elimination reactions.

[2] Some of these reactions are believed to be concerted pericyclic processes, as evidenced by stereospecificity that is consistent with the conservation of orbital symmetry.

The absence of cyclobutane from the decomposition of the isodiazene derived from the saturated 5-membered azacycle is evidence against radical intermediates, and the process is also believed to be concerted and pericyclic.

Due to the facile elimination of N2, most isodiazenes can only be isolated in a matrix at cryogenic temperatures.

[4] Isodiazenes have been observed to serve as ligands in transition metals complexes, including those of molybdenum and vanadium.