Isodurene or 1,2,3,5-tetramethylbenzene is an organic compound with the formula C6H2(CH3)4, classified as an aromatic hydrocarbon.

It is a flammable colorless liquid which is nearly insoluble in water but soluble in organic solvents.

[1] Isoodurene can be prepared from mesitylene, which is converted to mesityl bromide.

The latter reacts with magnesium to give the Grignard reagent, which can be alkylated with dimethyl sulfate: [2] Industrially, isodurene can be isolated from the reformed fraction of oil refineries.

It may also be produced by methylation of toluene, xylenes, and trimethylbenzenes.