[4] Side effects of isoflurane include a decreased ability to breathe (respiratory depression), low blood pressure, and an irregular heartbeat.

[3] Serious side effects can include malignant hyperthermia or high blood potassium.

General anaesthesia with isoflurane reduces plasma endocannabinoid AEA concentrations, and this could be a consequence of stress reduction after loss of consciousness.

[23] Isoflurane can cause a sudden decrease in blood pressure due to dose-dependent peripheral vasodilation.

[13] Animal studies have raised safety concerns of certain general anesthetics, in particular ketamine and isoflurane, in young children.

The risk of neurodegeneration was increased in combination of these agents with nitrous oxide and benzodiazepines such as midazolam.

[24] Biophysical studies using NMR spectroscopy has provided molecular details of how inhaled anesthetics interact with three amino acid residues (G29, A30 and I31) of amyloid beta peptide and induce aggregation.

[25] This area is important as "some of the commonly used inhaled anesthetics may cause brain damage that accelerates the onset of Alzheimer's disease".