Isotryptamine, also known as 2-(1-indolyl)ethylamine, is a chemical compound and positional isomer of tryptamine (2-(3-indolyl)ethylamine).

[1] A variety of isotryptamine derivatives, or substituted isotryptamines, have been developed, including serotonergic psychedelics and psychoplastogens like 6-MeO-isoDMT;[2][3] non-hallucinogenic psychoplastogens like isoDMT, 5-MeO-isoDMT, and AAZ-A-154 (DLX-001);[4][5][6][7] serotonin 5-HT2C receptor agonists like (S)-5,6-difluoro-isoAMT, Ro60-0175 ((S)-5-fluoro-6-chloro-isoAMT), and PNU-181731;[8][9][10][11][12] serotonin 5-HT6 receptor modulators;[13][14][15] and dual monoamine releasing agents and serotonin receptor agonists like isoAMT (PAL-569).

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