It is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack.

Itraconazole also inhibits an important cytochrome liver enzyme (CYP 450 3A4) which is needed to metabolize isradipine and other calcium channel blockers.

[5] Tizanidine demonstrates anti-hypertensive effects and should be avoided in patients taking isradipine due to the possibility of synergism between both medications.

[2] Severe hypotension was reported with fentanyl anesthesia when it was combined with other calcium channel blockers.

Even though isradipine, another calcium channel blocker, has not been used in conjunction with fentanyl anesthesia in any studies, caution is advised.