Exclusively sold in the United States and Costa Rica, the Axiom was built alongside the Rodeo in Lafayette, Indiana, at Subaru Isuzu Automotive, Inc.

The XS trim had features like fog lamps, a sunroof, heated front seats, an auto-dimming mirror with Homelink, 12-speaker premium audio, and leather upholstery.

The Axiom is available with a Torque-On-Demand four-wheel drive system, a direct-injection 6VE1-DI V6 engine and an Aisin Warner AW30-40LS automatic transmission was added in 2004, boosting power from 230 to 250 hp (172 to 186 kW).

Chinese manufacturer Great Wall later copied the design of the Axiom for their Haval H3/Hover SUV, albeit with a minor restyling of the body.

The 2001 movie Spy Kids and its 2002 sequel featured an Isuzu Axiom as part of a promotion, even having a lenticular poster and an RC car made by RadioShack.