One city and ninety-one villages were located in Iziaslav Raion.

The raion was abolished on 18 July 2020 as part of the administrative reform of Ukraine, which reduced the number of raions of Khmelnytskyi Oblast to three.

The Horyn, Vilia, Homora, Hnylyi Rig and other rivers flowed through the district.

At the time of disestablishment, the raion consisted of three hromadas:[4] From 1923 to 1932 the district was part of the Shepetivka region, then from 1932 to 1937 it was part of the Vinnytsia region.

Finally Iziaslav Raion was formed September 23, 1959.