Its administrative center was Slavuta which was incorporated separately as city of oblast significance and did not belong to the raion.

It was a large raion and ranked as the 7th among the largest with respect to the total area (1 162 km² corresponding to 5.6% of the total area of Khmelnytskyi Oblast).

The Horyn, Korchyk, Tsvitoha and other rivers flowed through the district.

At the time of disestablishment, the raion consisted of four hromadas:[4] From 1923 to 1932 the district was part of Shepetivka region, then from 1932 to 1937 it was part of the Vinnytsia Oblast.

Finally Slavuta Raion was formed September 23, 1959.