[13] At the conclusion of the pre-draft process, Doyle was projected to be a seventh round pick or priority undrafted free agent by NFL draft experts and scouts.

[15][16] Throughout training camp, Doyle competed to be a backup tight end against Taylor Thompson, Brandon Barden, and Martell Webb.

[17] On August 31, 2013, the Tennessee Titans waived Doyle as part as their final roster cuts, but planned to sign him to their practice squad after clearing waivers.

[19][20] Head coach Chuck Pagano named Doyle the fourth tight end on the Colts' depth chart to begin the regular season, behind Dwayne Allen, Coby Fleener, and Dominique Jones.

[21] He made his professional regular season debut in the Indianapolis Colts' 24–20 loss to the Miami Dolphins in Week after Dwayne Allen was placed on injured reserve due to a hip injury he sustained in the season-opener.

[22][23] On October 20, 2013, Doyle caught his first career reception on a seven-yard pass by quarterback Andrew Luck before being tackled by Danny Trevathan during the third quarter of a 39–33 win against the Denver Broncos in Week 7.

[24] The following game, he was promoted to being the primary backup on the depth chart behind Coby Fleener and earned his first career start during a 27–25 win at the Houston Texans in Week 9 after the Colts released Dominique Jones.

[26] On January 4, 2014, Doyle appeared in his first career playoff game as the Colts defeated the Kansas City Chiefs 45–44 in the AFC Wild Card Round.

[27] On January 11, 2014, Doyle started in his first career playoff game and caught one pass for seven-yards during a 43–22 loss at the New England Patriots in the AFC Divisional Round.

[28] During training camp, Doyle competed for a roster spot as a backup tight end against Weslye Saunders and Erik Swoope.

[29] Head coach Chuck Pagano named Doyle the third tight end on the Colts' depth chart to begin the regular season, behind Dwayne Allen and Coby Fleener.

[36][37][38] Head coach Chuck Pagano named Doyle the third tight end on the depth chart to begin the regular season, behind Dwayne Allen and Coby Fleener.

[44] On April 24, 2016, Doyle accepted his one-year, $1.67 million restricted free agent tender after he did not receive any control offers from any other team.

[45] Doyle entered training camp slated as the secondary starting tight end on the depth chart after Coby Fleener departed during free agency.

Head coach Chuck Pagano officially named Doyle and Dwayne Allen the starting tight ends to begin the regular season.

[51] Head coach Chuck Pagano named Doyle the starting tight end to begin the regular season in 2017.

[52] In Week 4, Doyle caught five passes for 27 receiving yards before exiting in the third quarter of a 46–18 loss at the Seattle Seahawks due to a concussion.