As a result, the Colts fired general manager Ryan Grigson after five seasons with the team, although head coach Chuck Pagano returned the next year.

Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve On February 16, the NFL announced that the Colts would play the Green Bay Packers in the Pro Football Hall of Fame Game.

Indy was outscored 21–7 after Turbin's touchdown, including a pick six by Aqib Talib and a scoop and score by Shane Ray off a Von Miller strip sack of Andrew Luck.

Brandon McManus would also kick two field goals in that stretch as the Broncos advanced to 2–0 and the Colts fell to 0–2.

Although the Colts took an early lead in the first quarter, the Chargers kept the game close and a Josh Lambo field goal put them ahead midway through the fourth quarter; however, a 63-yard pass from Andrew Luck to T. Y. Hilton restored the Colts' advantage with less than a minute remaining, giving them their first win of the season.

The Colts led 23–9 with less than three minutes to play, but a comeback by the Texans forced overtime, where they would win on a field goal.

Quarterback Andrew Luck did not play due to a concussion, and his replacement Scott Tolzien was unable to prevent a 28–7 defeat, although he did throw a five-yard touchdown pass to Donte Moncrief early in the second quarter.

With the loss, the Colts fell to 7–8 and were officially eliminated from playoff contention for the second year in a row.

The Jaguars took a 17–0 lead during the second quarter, but the Colts were able to pull it back to 17–17 as the game moved into its final period.

The Jaguars regained the lead with a 41-yard Jason Myers field goal inside the two-minute warning, but Andrew Luck led the Colts on a 75-yard drive that culminated with a 1-yard touchdown pass to Jack Doyle with four seconds remaining.