Zoboli in Rome was enrolled as member of the Congregation of the Virtuosi at the Pantheon in 1718 and subsequently the Accademia di San Luca on 2 September 1725, during the period when the painter Giuseppe Bartolomeo Chiari was prince of the academy.
In August 1718, Zoboli joined the Archconfraternity of the Sacred Stigmata of St. Francis, a group celebrating the miracle of the Santissime Stimmate di San Francesco.
For several scholars, including Rudolph, Zoboli "painted works that show a surprising anticipation of Neoclassicism of the second half of the 18th century", and thus was an early exponent of this move away from the Baroque.
For Vittorio Casale, Zoboli expressed a "conscious proto-neoclassicism" and interpreted his aesthetic ideals of a rationalistic Arcadia "opposed to the effusions of the Baroque".
Also famous is the work depicting Saint Francis of Sales and Blessed Joan Frances de Chantal, located in the Visitation Monastery in Madrid.
In 1747, alongside Giovanni Paolo Panini, Zoboli compiled the inventory of the Sacchetti collection purchased by Pope Benedict XIV to form the initial nucleus of the nascent Pinacoteca Capitolina.
Additionally, about thirty works destined for churches and palaces in Rome are also untraceable, according to a detailed list published by Maria Barbara Guerrieri Borsoi.
By express testamentary will, he was buried in the Chiesa delle Santissime Stimmate - Church of the Most Holy Stigmata of St. Francis in Rome, although the exact location of his tomb is currently unknown.