[3] xPosed told the story of Rodriguez's life and struggle to come out to his religious family as well as his career on stage and in Queer Eye.

[2] In November 2005, while Queer Eye was on filming hiatus, he joined the cast of The Producers on Broadway for three months, playing the role of Carmen Ghia.

In March 2011, Rodriguez made an appearance in an episode of NBC's Harry's Law, titled "Send in the Clowns", as a transgender woman fired after an affair with a club owner was exposed.

In November 2011, Rodriguez appeared in an episode of How I Met Your Mother titled "The Rebound Girl", playing the husband of Barney Stinson's brother.

Rodriguez regularly guest performs in Cookin' with Gas , a long-running all improv show, at The Groundlings Theatre in Los Angeles.

On Malibu Country, Rodriguez was a regular cast member, playing record industry executive, Geoffrey.

This was a contest on Bravo in which 50 actors and actresses won a trip to New York City to work with Broadway professionals.

Rodriguez released his first single, "Love Is Good", on the indie record label Arrive at Eleven Productions in March 2003.

Rodriguez is also a co-author of the New York Times bestselling book[8][9] Queer Eye for the Straight Guy: The Fab Five's Guide to Looking Better, Cooking Better, Dressing Better, Behaving Better, and Living Better (Published by Clarkson Potter, 2004).