[1] Guyton began his collegiate career at Notre Dame, redshirting his true freshman season.

He left the program after being suspended for disciplinary reasons and transferred to Trinity Valley Community College.

He committed to transfer to the University of North Texas over offers from Marshall, Bowling Green and West Virginia.

Following the end of the season, Guyton announced he would be forgoing his final year of NCAA eligibility to enter the 2019 NFL draft.

[11] In Week 4 against the Tampa Bay Buccaneers, Guyton recorded one reception for a 72-yard receiving touchdown during the 38–31 loss.

[16] In Week 3 of the 2022 season, Guyton suffered a torn ACL and was placed on season-ending injured reserve on September 27, 2022.