James Barnes Wyngaarden (October 19, 1924 – June 14, 2019) was an American physician, researcher and academic administrator.

[4] He trained in internal medicine at the Massachusetts General Hospital and did postdoctoral work at the Public Health Research Institute of the City of New York under DeWitt Stetten, Jr. After serving as research associate at NIH from 1953 to 1956, he moved to Duke University and in 1959 became director of the medical research training program there as well as associate professor of medicine and biochemistry.

[5] Wyngaarden served as the 12th director of National Institutes of Health from April 1982 to July 1989.

After his tenure, he became an Associate Director at the Office of Science and Technology Policy.

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