James Wylie Huffman (September 13, 1894 – May 20, 1980) was an American lawyer and Democratic Party politician from Ohio.

[2] Huffman served as Donahey's executive assistant during his governorship, and was a member of the state public utilities commission from 1927 to 1929.

[1] In 1945, Senator Harold Hitz Burton resigned in order to accept appointment to the United States Supreme Court.

[1] Lausche appointed Huffman to fill the vacancy and he served in the U.S. Senate from October 8, 1945 to November 5, 1946, when Kingsley A. Taft defeated him in the election to complete the remainder of the term.

[1][2] After leaving the Senate, Huffman resumed practicing law until 1957, when he became president of the Motorists Mutual Insurance Company.