[2] Additionally, she is the scientific director of The General Medical Sciences and Cancer Institutes’ structural biology facility at the Advanced Photon Source (GM/CA @ APS).

Smith's research group focus on the understanding of proteins to the molecular level through structural biology.

The main experimental technique employed in her lab is X-ray crystallography used to elucidate protein structures.

Janet's lab has also worked towards method development for rapid structure determination.

[7] Her lab contributed to the development of multiwavelength anomalous diffraction (MAD) used routinely for structure determination.