In 2018, with support from the U-M Biosciences Initiative,[5] the institute began expanding the cryo-EM program and also launched its Natural Products Discovery Core.

Roger D. Cone began his tenure as the Mary Sue Coleman Director of the University of Michigan Life Sciences Institute in September 2016.

A leading researcher in brain regulation of body weight, Cone also serves as vice provost and director of U-M's biosciences initiative.

In 2002, Mary Sue Coleman, U-M's president, appointed cell biologist and expert on insulin signaling Alan R. Saltiel as director.

[citation needed] Its 23 faculty members lead labs specializing in a wide range of life sciences disciplines, including: In addition to faculty labs, the institute is home to research cores that provide services to the institute, the university, and external partners: A high-throughput screening (HTS) facility is a central component of the Center for Chemical Genomics (CCG).