The hospital was formally inaugurated on 6 July 1973 by the erstwhile Prime Minister, Indira Gandhi.

The hospital got substantial publicity in the late 1970s when Jayaprakash Narayan was admitted for treatment of kidney failure by the nephrologist M. K. Mani.

[1] In the early 1980s the laboratories run there by P. R. Krishnaswamy had the first fully automated Kontron biochemistry analyzers, an electron microscope and an aminoacid analyser.

Dr Rindani, the then medical director, stood firm, The police were called in and a court injunction prohibiting assembly of the agitating workers was obtained.

[3][4][5] Jaslok Hospital is located at Dr. G. Deshmukh Marg., Peddar Road, South Mumbai, overlooking the Arabian Sea.