Hunter on the UPN television sitcom Eve, as Dr. Otis Cole on ABC's Off the Map, and as Dr. Ben Warren on Grey's Anatomy and its spinoff Station 19.

[3] In 1996, George was cast as lifeguard Michael Bourne on the soap opera Sunset Beach, a role he played from the series' first episode on January 6, 1997, until the show ended on December 31, 1999.

In 2000, he made a successful stage appearance in Rita Dove's drama The Darker Face of the Earth at the Fountain Theatre in Los Angeles, where he played the male lead of Augustus.

He has also appeared on many ABC series, such as What About Brian, Eli Stone, Eastwick, Off the Map, Grey's Anatomy, and guest starred on Castle and Desperate Housewives.

He currently stars in Grey's Anatomy as Dr Ben Warren, a surgical resident and former firefighter of Seattle Fire Station 19.