Originally from Valls, he moved to Tarragona to stay with his uncle Pere Huguet, who was also a painter.
A retablo from Huguet is in the Monastery of Pedralbes, while another, depicting the Adoration of the Magi (or Epiphany) is housed in the Chapel of St. Agatha in Barcelona's Palau Reial Major.
A number of works by Huguet, including The Consecration of Saint Augustine, are held in the collection of the Museu Nacional d'Art de Catalunya in Barcelona, Spain.
The first documented piece that Huguet was commissioned to paint was the high altarpiece of the Church of Sant Antoni Abat in Barcelona in 1454.
He also painted the central panel from the altarpiece of the Chapel of the Esparto Workers' and the Glazier's Guild in Barcelona Cathedral, which he finished in 1468.