Perllissier departed from Wamakersvallei to Kuruman, South Africa to do mission work among the Tswana people (Zeerust).
Local infighting between rival tribes caused him to move to the area north of the Orange River in 1833, to a site where the London Missionary Society had an unsuccessful attempt to start a mission station among the Khoi people.
Besides his mission work, Pellissier made a great contribution towards practical education and medicine among the local people.
Pellissier married Martha Thorpe Murray (b.23 February 1814, d.17 October 1887) a 1820 Settlers child.
This links the Pellissier family to significant political events and figures in South African history.