Jefferson is a town in Grant County, Oklahoma, United States.

According to the United States Census Bureau, the town has a total area of 0.3 square miles (0.78 km2), all land.

The racial makeup of the town was 89.19% White, 2.70% Native American, 8.11% from other races.

31.3% of all households were made up of individuals, and 6.3% had someone living alone who was 65 years of age or older.

There were 20.0% of families and 18.9% of the population living below the poverty line, including no under eighteens and 66.7% of those over 64.