Established in 1890 by the Sisters of Providence as St. John Hospital, it is presently independently owned and operated by Jefferson County Public Hospital District No.

2, which had been formed following a special election on August 15, 1961 authorizing establishment of the District.

[5] In 2004, the name was again updated to Jefferson Healthcare Hospital, to better reflect its status as the nucleus of an integrated healthcare system that had grown to include a number of hospital-based and community clinics.

[3][4] In May 2013, the hospital revealed plans for a new 50,000-square-foot (4,600 m2) emergency and specialty services building.

[6] The project was estimated to cost between $15 and 20 million, and broke ground to begin renovations in June 2015.